Cell-in-cell phenomena in cancer Journal Article

Authors: Fais, S.; Overholtzer, M.
Article Title: Cell-in-cell phenomena in cancer
Abstract: Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest whole neighbouring cells to form such structures, and the consequences of cell-in-cell formation on cancer progression have been elucidated. In this Opinion article, we discuss how two related cell-in-cell processes, cell cannibalism and entosis, are regulated and how these mechanisms promote cancer progression. We propose that cannibalistic activity is a hallmark of cancer that results in part from selection by metabolic stress and serves to feed aggressive cancer cells. © 2018, Springer Nature Limited.
Journal Title: Nature Reviews Cancer
Volume: 18
Issue: 12
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2018-12-01
Start Page: 758
End Page: 766
Language: English
DOI: 10.1038/s41568-018-0073-9
PUBMED: 30420767
PROVIDER: scopus
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
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