Novel positron-emitting radiopharmaceuticals Book Section
| Authors: | Sarparanta, M.; Demoin, D. W.; Cook, B. E.; Lewis, J. S.; Zeglis, B. M. |
| Editors: | Strauss, H. W.; Mariani, G.; Volterrani, D.; Larson, S. M. |
| Article/Chapter Title: | Novel positron-emitting radiopharmaceuticals |
| Abstract: | Over the past two decades, nuclear imaging has transformed cancer care. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) can provide clinicians with functional and biochemical information about tumor tissue that complement the anatomical data acquired through magnetic resonance imaging (MRI) and computed tomography (CT). In this chapter, we highlight a number of emerging radiotracers in oncology that are currently employed in clinical trials in the USA and worldwide yet are awaiting regulatory approval in the USA. The radiotracers discussed range from small molecule probes that target cellular transport mechanisms and metabolic pathways to antibody- based agents that target cell-surface receptors. In order to help the reader appreciate the diversity and potential of each of these imaging agents, we present the underlying mechanisms of each agent's targeting and trapping in tumor tissue and provide examples of clinical studies in diverse cancer types as well as descriptions of the utility of each tracer for staging and treatment monitoring. © Springer International Publishing Switzerland 2017. All rights reserved. |
| Keywords: | oncology; hypoxia; integrin; zirconium-89; amino acid transport; somatostatin receptor; imaging agent; cellular proliferation; radiotracer; nuclear imaging; indium-111; technetium-99m; fluorine-18; carbon-11; bombesin receptor; lipid biosynthesis; gallium- 68; positron emission tomography, pet; prostate-specific membrane antigen, psma; single photon emission tomography, spect; steroid hormone receptor |
| Book Title: | Nuclear Oncology: From Pathophysiology to Clinical Applications. 2nd ed |
| Volume: | 1 |
| ISBN: | 978-3-319-26234-5 |
| Publisher: | Springer |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2017-01-01 |
| Start Page: | 129 |
| End Page: | 171 |
| Language: | English |
| DOI: | 10.1007/978-3-319-26236-9_87 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 7 -- Export Date: 3 December 2018 -- Source: Scopus |
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