The current status of positron-emission tomography scanning in the evaluation and follow-up of patients with head and neck cancer Journal Article
| Authors: | Kutler, D. I.; Wong, R. J.; Schoder, H.; Kraus, D. H. |
| Article Title: | The current status of positron-emission tomography scanning in the evaluation and follow-up of patients with head and neck cancer |
| Abstract: | Purpose of review: Functional imaging has increasingly become an important diagnostic tool for head and neck cancer and as its availability increases so will its utilization. Positron-emission tomography using the radiotracer [18F]fluoro-2-deoxy-D-glucose is the most commonly used functional imaging technology and it has the potential to improve the staging and detection of head and neck tumors compared with conventional imaging techniques such as computed tomography or magnetic resonance imaging. Recent findings: The combination of [18F]fluoro-2-deoxy-D-glucose and positron-emission tomography contributes valuable information in localizing a primary tumor in patients with an unknown primary and neck metastases, in the staging of primary head and neck cancer, in the detection of residual disease following definitive chemoradiation, and in the detection of recurrent disease. New technologies have been recently introduced using the combination of computed tomography and positron-emission tomography that allows exact anatomical correlation with areas of increased tracer uptake. In addition, new tracers may allow quantification of important cellular processes related to tumor proliferation or identification of tumors that may respond to certain targeted therapies. Summary: [18F]Fluoro-2-deoxy-D-glucose and positron-emission tomography are increasingly being used as a clinical imaging modality in the complex management of head and neck cancer. In particular, its clinical value in the evaluation of the unknown primary, and the evaluation of recurrent or residual disease, is well established and has shown to be more accurate than conventional imaging modalities. © 2006 Lippincott Williams & Wilkins. |
| Keywords: | cancer chemotherapy; unclassified drug; review; cancer localization; intensity modulated radiation therapy; squamous cell carcinoma; carcinoma, squamous cell; cancer radiotherapy; combined modality therapy; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; lymph node metastasis; staging; neoplasm staging; diagnostic accuracy; lymphoscintigraphy; sensitivity and specificity; radiopharmaceuticals; sentinel lymph node biopsy; computer assisted tomography; neoplasm recurrence, local; tomography, x-ray computed; diagnostic value; minimal residual disease; head and neck cancer; head and neck neoplasms; systematic review; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; neoplasm metastasis; recurrent disease; thorax radiography; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; detection; physical examination; tracer; fluorine 18; choline c 11; false positive result; zirconium 89; methionine c 11; neoplasms, unknown primary; carbon 11; neck metastasis; evaluation and follow up; positron-emission tomography/computed tomography; squamous cell carcinoma of the upper aerodigestive tract; arabinoside i 123; diacetylbis(n4 methylthiosemicarbazone) cu 63; tyrosine f 18 |
| Journal Title: | Current Opinion in Otolaryngology & Head and Neck Surgery |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 1068-9508 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2006-04-01 |
| Start Page: | 73 |
| End Page: | 81 |
| Language: | English |
| DOI: | 10.1097/01.moo.0000193182.92568.8d |
| PUBMED: | 16552262 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: COOSF" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work