Nanoparticles and radiotracers: Advances toward radionanomedicine Journal Article
| Authors: | Pratt, E. C.; Shaffer, T. M.; Grimm, J. |
| Article Title: | Nanoparticles and radiotracers: Advances toward radionanomedicine |
| Abstract: | In this study, we cover the convergence of radiochemistry for imaging and therapy with advances in nanoparticle (NP) design for biomedical applications. We first explore NP properties relevant for therapy and theranostics and emphasize the need for biocompatibility. We then explore radionuclide-imaging modalities such as positron emission tomography (PET), single-photon emission computed tomography (SPECT), and Cerenkov luminescence (CL) with examples utilizing radiolabeled NP for imaging. PET and SPECT have served as diagnostic workhorses in the clinic, while preclinical NP design examples of multimodal imaging with radiotracers show promise in imaging and therapy. CL expands the types of radionuclides beyond PET and SPECT tracers to include high-energy electrons (β−) for imaging purposes. These advances in radionanomedicine will be discussed, showing the potential for radiolabeled NPs as theranostic agents. WIREs Nanomed Nanobiotechnol 2016, 8:872–890. doi: 10.1002/wnan.1402. For further resources related to this article, please visit the WIREs website. © 2016 Wiley Periodicals, Inc. |
| Keywords: | positron emission tomography; computerized tomography; biocompatibility; nanoparticles; radioactive tracers; radioisotopes; radionuclide imaging; positron emission tomography (pet); theranostics; medical applications; single photon emission computed tomography; biomedical applications; cerenkov; multi-modal imaging; particle beams; high-energy electron; theranostic agents |
| Journal Title: | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology |
| Volume: | 8 |
| Issue: | 6 |
| ISSN: | 1939-5116 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2016-11-01 |
| Start Page: | 872 |
| End Page: | 890 |
| Language: | English |
| DOI: | 10.1002/wnan.1402 |
| PROVIDER: | scopus |
| PMCID: | PMC5035177 |
| PUBMED: | 27006133 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 November 2016 -- Source: Scopus |
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