Mitogenic response to TGF-β in 3T3-F442A cells Journal Article

  


Authors: Jeoung, D. I.; Tang, B.; Sonenberg, M.
Article Title: Mitogenic response to TGF-β in 3T3-F442A cells
Abstract: In 3T3-F442A cells, TGF-β caused cellular proliferation in a time and dose-dependent manner. TGF-β induced cyclin D1 and cdk2 proteins in 3T3-F442A cells. The mitogenic effect of TGF-β was specific in nature. The antimitogenic agent, hGH, inhibited the mitogenic effect of TGF-β and was associated with inhibition of cyclin D1 expression. The protein kinase c inhibitor, staurosporine, inhibited the mitogenic effect of TGF-β. Taken together, these results suggest that TGF-β affects expression levels of cell cycle-regulated proteins and its mitogenic effect is mediated through protein kinase C in 3T3-F442A cells. © 1995 Academic Press, Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 216
Issue: 3
ISSN: 0006-291X
Publisher: Elsevier Science, Inc.  
Date Published: 1995-11-22
Start Page: 964
End Page: 969
Language: English
DOI: 10.1006/bbrc.1995.2714
PROVIDER: scopus
PUBMED: 7488218
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028971052&doi=10.1006%2fbbrc.1995.2714&partnerID=40&md5=72be79eb2c8221379f07936e769fae54
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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MSK Authors
  1. Baiqing Tang
    14 Tang
  2. Martin Sonenberg
    28 Sonenberg
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