A total synthesis of taxol Journal Article


Authors: Masters, J. J.; Link, J. T.; Snyder, L. B.; Young, W. B.; Danishefsky, S. J.
Article Title: A total synthesis of taxol
Abstract: The intramolecular Heck reaction of 1 to 2 is the cornerstone of this total synthesis of taxol (see conversion below). The route starts with the (S)‐Wieland Miescher ketone, and the oxetane ring is installed early in the synthesis. Elaboration to a CD ring fragment, addition of an A ring nucleophile, and further manipulations yield the appropriate starting material (1) for the Heck reaction. After this key step yielding 2, the synthesis of baccatin III (and thence taxol) concludes with the cleavage of the exo double bond at C‐10 and oxygenation at C‐9 and C‐13. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
Keywords: taxol; total syntheses; heck reactions; baccatin iii
Journal Title: Angewandte Chemie: International Edition in English
Volume: 34
Issue: 16
ISSN: 0570-0833
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA  
Date Published: 1995-09-01
Start Page: 1723
End Page: 1726
Language: English
DOI: 10.1002/anie.199517231
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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