Total synthesis of baccatin III and taxol Journal Article

  


Authors: Danishefsky, S. J.; Masters, J. J.; Young, W. B.; Link, J. T.; Snyder, L. B.; Magee, T. V.; Jung, D. K.; Isaacs, R. C. A.; Bornmann, W. G.; Alaimo, C. A.; Coburn, C. A.; Di Grandi, M. J.
Article Title: Total synthesis of baccatin III and taxol
Abstract: An intramolecular Heck reaction (90 → 91) serves as the key step in the total synthesis of the titled compounds. The synthetic route is based on utilizing the Wieland-Miescher ketone (5) as a matrix to provide the C and D rings of the targets and to provide functionality implements for joining this sector to an A ring precursor (6). Catalytically induced enantiotopic control and early emplacement of the oxetane are other features of the route.
Journal Title: Journal of the American Chemical Society
Volume: 118
Issue: 12
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 1996-03-27
Start Page: 2843
End Page: 2859
Language: English
DOI: 10.1021/ja952692a
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-11044223276&doi=10.1021%2fja952692a&partnerID=40&md5=1bbc39b3cf080a66e623ef820134806a
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. William Bornmann
    112 Bornmann
  2. Samuel J Danishefsky
    539 Danishefsky
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