A three-step entry to the aspirochlorine family of antifungal agents Journal Article

  


Authors: Wu, Z.; Williams, L. J.; Danishefsky, S. J.
Article Title: A three-step entry to the aspirochlorine family of antifungal agents
Abstract: The quest for superior antifungal agents will be aided by the unprecedented sulfur migration of an epidithioketopiperazine (EDKP) in a highly stereoselective manner and in high yield. The rearrangement provides a short route to compounds in the same family as aspirochlorine (1), a potent inhibitor of fungal protein synthesis. In this family one of the dithio sulfur atoms is anchored to a dihydrobenzofuran ring that is spiro fused to the piperazine ring.
Keywords: unclassified drug; antifungal agent; drug structure; protein synthesis; natural product; piperazine derivative; structure analysis; antifungal agents; aspergillus; proton transport; fungal protein; stereochemistry; rearrangements; natural products; sulfur; article; sulfur heterocycles; aspirochlorine; chlorine derivative; dihydrobenzofuran derivative; epidithiodiketopiperazine
Journal Title: Angewandte Chemie - International Edition
Volume: 39
Issue: 21
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2000-11-03
Start Page: 3866
End Page: 3868
Language: English
DOI: 10.1002/1521-3773(20001103)39:21<3866::aid-anie3866>3.0.co;2-e
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034602034&partnerID=40&md5=1b6d0b9d8dca2eb3007d23cae8a3cb2c
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Lawrence J Williams
    14 Williams
  2. Samuel J Danishefsky
    539 Danishefsky
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