Gelsemine: A thought-provoking target for total synthesis Journal Article
| Authors: | Lin, H.; Danishefsky, S. J. |
| Article Title: | Gelsemine: A thought-provoking target for total synthesis |
| Abstract: | Gelsemine and 21-oxogelsemine have been synthesized through several routes. This Review focuses on the comparison of the different strategies to assemble the bicyclo[3.2.1]octane core, to introduce the bridgehead quaternary C20 to form the pyrrolidine moiety, to construct the oxindole residue, and to close the tetrahydropyran ring en route to gelsemine. |
| Keywords: | unclassified drug; review; comparative study; molecular structure; cyclization; natural product; alkaloids; reaction analysis; synthesis; total synthesis; synthesis (chemical); stereochemistry; chemical bond; carbon; residues; natural products; organic compounds; gelsemine; pyrrolidine derivative; polycycles; stereo selective synthesis; 12 oxogelsemine; bicyclo[3.2.1]octane derivative; oxindole; polycyclic hydrocarbon; tetrahydropyran derivative; gelsemium; photochemical processes |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 42 |
| Issue: | 1 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2003-01-03 |
| Start Page: | 36 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.1002/anie.200390048 |
| PUBMED: | 19757588 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
