Stereocontrolled syntheses of C-aryl taxanes by intramolecular Heck olefination. Novel instances of diastereofacial guidance by proximal coordination Journal Article
| Authors: | Young, W. B.; Masters, J. J.; Danishefsky, S. |
| Article Title: | Stereocontrolled syntheses of C-aryl taxanes by intramolecular Heck olefination. Novel instances of diastereofacial guidance by proximal coordination |
| Abstract: | Stereospecific syntheses of baccatin III constructs bearing an aromatic C-ring (2a and 2b) have been demonstrated. A key step involves the use of an intramolecular Heck olefination reaction to form the C10-C11 bond (see transformations 15 → 16 and 27 → 28). Novel stereospecific reactions en route to 2a and 2b were also discovered (see 8 → 10, 8 → 23, 13 → 14, and 25 → 26). © 1995, American Chemical Society. All rights reserved. |
| Keywords: | drug synthesis; taxane derivative; reaction analysis; stereochemistry; article; baccatin iii |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 117 |
| Issue: | 19 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 1995-05-17 |
| Start Page: | 5228 |
| End Page: | 5234 |
| Language: | English |
| DOI: | 10.1021/ja00124a006 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
