A novel intramolecular Heck reaction: Synthesis of a cholesterol‐baccatin III hybrid Journal Article
| Authors: | Masters, J. J.; Jung, D. K.; Danishefsky, S. J.; Snyder, L. B.; Park, T. K.; Issacs, R. C. A.; Alaimo, C. A.; Young, W. B. |
| Article Title: | A novel intramolecular Heck reaction: Synthesis of a cholesterol‐baccatin III hybrid |
| Abstract: | Despite strong repulsion between the methyl groups, the intramolecular Heck reaction of cyclohexenyl trifluoromethanesulfonate 1, available from 5‐α‐cholestan‐3‐one, proceeds in 50% yield. The product of the Heck reaction can be converted in a few subsequent steps into the cholesterol‐baccatin III hybrid 2. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany |
| Keywords: | taxol; heck reactions; natural products synthesis; baccatin iii |
| Journal Title: | Angewandte Chemie: International Edition in English |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 0570-0833 |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| Date Published: | 1995-03-07 |
| Start Page: | 452 |
| End Page: | 455 |
| Language: | English |
| DOI: | 10.1002/anie.199504521 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
