Intra-arterial and oral digoxin therapy for retinoblastoma Journal Article

  


Authors: Patel, M.; Paulus, Y. M.; Gobin, Y. P.; Djaballah, H.; Marr, B.; Dunkel, I. J.; Brodie, S.; Antczak, C.; Folberg, R.; Abramson, D. H.
Article Title: Intra-arterial and oral digoxin therapy for retinoblastoma
Abstract: Purpose: Preclinical studies demonstrate that cardiac glycosides such as ouabain and digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine model of retinoblastoma. Methods: Based on these findings, we report a case of intra-arterial followed by systemic oral digoxin therapy in a patient with unilateral retinoblastoma that had failed prior intra-arterial chemotherapy. Results: Oral administration of digoxin produced no effect, while intra-arterial digoxin therapy produced a modest but measurable response that was likely limited by the inability to achieve sustained drug concentration in the eye. Conclusions: This case highlights both the potential promise and limitations of cardiac glycoside therapy in retinoblastoma. © 2011 Informa Healthcare USA, Inc.
Keywords: cancer chemotherapy; child; preschool child; child, preschool; case report; cancer growth; drug efficacy; drug safety; drug withdrawal; treatment duration; antineoplastic agents; drug megadose; multiple cycle treatment; melphalan; digoxin; retinoblastoma; retinal neoplasms; cancer regression; cancer size; murinae; infusions, intra-arterial; drug tissue level; enucleation; ophthalmic artery; retina detachment; eye enucleation; drug dose increase; drug substitution; drug treatment failure; administration, oral; absence of side effects; ecg abnormality; cryotherapy; intra-arterial; cardiac glycosides; digoxin blood level; eye fundus; cardiotonic agents; strophanthus gratus
Journal Title: Ophthalmic Genetics
Volume: 32
Issue: 3
ISSN: 1381-6810
Publisher: Taylor & Francis Group  
Date Published: 2011-09-01
Start Page: 147
End Page: 150
Language: English
DOI: 10.3109/13816810.2010.544530
PROVIDER: scopus
PUBMED: 21446853
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80051707437&partnerID=40&md5=4e5ceb29f905864d4a55e1cd3d52fe61
Notes: --- - "Export Date: 3 October 2011" - "CODEN: OGENE" - "Source: Scopus"
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MSK Authors
  1. Brian Marr
    112 Marr
  2. Ira J Dunkel
    371 Dunkel
  3. Mrinali Mrugendra Patel
    5 Patel
  4. David H Abramson
    389 Abramson
  5. Scott Brodie
    38 Brodie
  6. Hakim Djaballah
    101 Djaballah
  7. Christophe Antczak
    40 Antczak
  8. Yannis Mantas Paulus
    3 Paulus
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