Hearing evaluations in children with retinoblastoma treated with intra-arterial carboplatin chemotherapy: A single institution review Review
| Authors: | Davis, M. E.; Guarini, E.; O’Connor, K.; Francis, J. H.; Abramson, D. H. |
| Review Title: | Hearing evaluations in children with retinoblastoma treated with intra-arterial carboplatin chemotherapy: A single institution review |
| Abstract: | Purpose: To determine whether the administration of intra-arterial carboplatin affected the hearing of children with retinoblastoma. Methods: Children with retinoblastoma who were treated with intra-arterial carboplatin chemotherapy were included. Hearing tests before chemotherapy including tympanometry, distortion product otoacoustic emissions, and audiogram (if achievable) were performed and repeated 3 to 9 months after concluding intra-arterial therapy. The study was approved by the institutional review board. Patients were identified from the retinoblastoma clinic when the treatment plan included intra-arterial carboplatin chemotherapy. Children were excluded if they had previous intra-arterial carboplatin or preexisting hearing loss but were included if they had systemic carboplatin and dosing was available. Tympanometry was performed to rule out inner ear fluid. All examinations were performed by a certified audiologist with the same equipment, calibrated regularly by a certified technician. Results: Twenty-two children (32 eyes) were evaluable. Because most children are diagnosed at a young age and are unable to participate in an audiogram, distortion product otoacoustic emission measurement was the primary measurement. No child displayed hearing loss. Conclusions: Intra-arterial chemotherapy with carboplatin did not cause ototoxicity in any child by distortion product otoacoustic emission measurement in contrast to systemic chemotherapy where ototoxicity is common. Distortion product otoacoustic emission levels were essentially unchanged from before to after intra-arterial chemotherapy in children with retinoblastoma. These findings suggest that intra-arterial carboplatin does not affect outer hair cell function, and distortion product otoacoustic emission tests can provide useful information when monitoring children at risk of developing carboplatin ototoxicity. © 2025 Slack Incorporated. All rights reserved. |
| Keywords: | child; clinical article; preschool child; child, preschool; retrospective studies; drug safety; antineoplastic agents; pathophysiology; follow up; follow-up studies; antineoplastic agent; prospective study; carboplatin; retinoblastoma; drug effect; retina tumor; retinal neoplasms; retrospective study; physiology; infant; diagnosis; intraarterial drug administration; infusions, intra-arterial; hearing; drug therapy; hearing impairment; hearing loss; acoustic impedance; procedures; pretest posttest design; hearing test; humans; human; male; female; article; acoustic impedance tests; hearing tests; otoacoustic emissions, spontaneous; distortion product otoacoustic emission; tympanometry; spontaneous otoacoustic emission |
| Journal Title: | Journal of Pediatric Ophthalmology and Strabismus |
| Volume: | 62 |
| Issue: | 1 |
| ISSN: | 0191-3913 |
| Publisher: | SLACK, Inc. |
| Date Published: | 2025-01-01 |
| Start Page: | 27 |
| End Page: | 32 |
| Language: | English |
| DOI: | 10.3928/01913913-20240807-02 |
| PUBMED: | 39254185 |
| PROVIDER: | scopus |
| PMCID: | PMC11757066 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Mary Elizabeth Davis -- Source: Scopus |
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