Thio FCMA intermediates as strong acyl donors: A general solution to the formation of complex amide bonds Journal Article

   


Authors: Rao, Y.; Li, X.; Danishefsky, S. J.
Article Title: Thio FCMA intermediates as strong acyl donors: A general solution to the formation of complex amide bonds
Abstract: (Chemical Equation Presented) Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles. © 2009 American Chemical Society.
Keywords: unclassified drug; chemical structure; molecular structure; molecular interaction; chemical reactions; chemical equations; reaction analysis; nitriles; chemical reaction; sulfur compounds; isonitriles; isonitrile derivative; organic chemistry; acyl donors; amide bond; general solutions; neutral conditions; novel methodology; thioacids; amides; amide; carboxylic acid; formimidate carboxylate mixed anhydride; n formylamide; n thioformylamide
Journal Title: Journal of the American Chemical Society
Volume: 131
Issue: 36
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2009-09-16
Start Page: 12924
End Page: 12926
Language: English
DOI: 10.1021/ja906005j
PUBMED: 19697932
PROVIDER: scopus
PMCID: PMC2756580
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-70349130818&partnerID=40&md5=0dffb4a20d83ac1a3b61557ab2927c05
Notes: --- - "Cited By (since 1996): 6" - "Export Date: 30 November 2010" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Yu Rao
    2 Rao
  2. Xuechen Li
    13 Li
  3. Samuel J Danishefsky
    539 Danishefsky
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