Mild, Pd-catalyzed stannylation of radioiodination targets Journal Article
| Authors: | Pickett, J. E.; Váradi, A.; Palmer, T. C.; Grinnell, S. G.; Schrock, J. M.; Pasternak, G. W.; Karimov, R. R.; Majumdar, S. |
| Article Title: | Mild, Pd-catalyzed stannylation of radioiodination targets |
| Abstract: | Trialkylstannanes are versatile precursors for chemical transformations, including radiolabeling with a variety of halogens, particularly iodine. In the present work a convenient, Pd-mediated stannylation method is presented that can be performed in an open flask. The method is selective for aryl iodides allowing selective stannylations in the presence of other halogen atoms. The reaction conditions are mild, making the method compatible with chemically sensitive bioactive compounds. © 2015 Elsevier Ltd.All rights reserved. |
| Keywords: | opioid; radioiodination; stannylation; sigma receptor; radioligand binding |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 25 |
| Issue: | 8 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2015-04-15 |
| Start Page: | 1761 |
| End Page: | 1764 |
| Language: | English |
| DOI: | 10.1016/j.bmcl.2015.02.055 |
| PROVIDER: | scopus |
| PMCID: | PMC4385467 |
| PUBMED: | 25777268 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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