Total synthesis and structural revision of (±)-tricholomalides A and B Journal Article
| Authors: | Wang, Z.; Min, S. J.; Danishefsky, S. J. |
| Article Title: | Total synthesis and structural revision of (±)-tricholomalides A and B |
| Abstract: | (Chemical Equation Presented) The neurotrophic diterpenoids, tricholomalides A and B, were synthesized in a concise fashion. Key transformations include a ketene [2 + 2] cycloaddition and a Grignard-type reaction. In the course of the synthesis, it was determined that the structures of tricholomalides A and B had originally been misassigned. © 2009 American Chemical Society. |
| Keywords: | controlled study; unclassified drug; drug structure; drug synthesis; chemical equations; total synthesis; synthesis (chemical); proton nuclear magnetic resonance; carbon nuclear magnetic resonance; [2 + 2] cycloaddition; diterpenoids; grignard; neurotrophic; diterpene; ketene derivative; tricholomalide a; tricholomalide b; cycloaddition; grignard reaction; x ray diffraction |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 131 |
| Issue: | 31 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2009-08-12 |
| Start Page: | 10848 |
| End Page: | 10849 |
| Language: | English |
| DOI: | 10.1021/ja9049433 |
| PROVIDER: | scopus |
| PMCID: | PMC2756578 |
| PUBMED: | 19722666 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: JACSA" - "Source: Scopus" |
