α-emitters for radiotherapy: From basic radiochemistry to clinical studies - Part 2 Journal Article

   


Authors: Poty, S.; Francesconi, L. C.; McDevitt, M. R.; Morris, M. J.; Lewis, J. S.
Article Title: α-emitters for radiotherapy: From basic radiochemistry to clinical studies - Part 2
Abstract: The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.
Keywords: radiotherapy; clinical trials; radiochemistry; α-emitters
Journal Title: Journal of Nuclear Medicine
Volume: 59
Issue: 7
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2018-07-01
Start Page: 1020
End Page: 1027
Language: English
DOI: 10.2967/jnumed.117.204651
PROVIDER: scopus
PUBMED: 29496984
PMCID: PMC6910645
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049404512&doi=10.2967%2fjnumed.117.204651&partnerID=40&md5=d9b9b19e936d010dfc3bf54b6cbf8a46
Notes: Article -- For Part 1 see https://synapse.mskcc.org/synapse/works/125978 -- Export Date: 1 August 2018 -- Source: Scopus
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MSK Authors
  1. Michael Morris
    577 Morris
  2. Michael R Mcdevitt
    144 Mcdevitt
  3. Jason S Lewis
    456 Lewis
  4. Sophie Poty
    10 Poty
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