Radiopharmaceuticals for cancer diagnosis and therapy: New targets, new therapies - Alpha-emitters, novel targets Review
| Authors: | Taunk, N. K.; Escorcia, F. E.; Lewis, J. S.; Bodei, L. |
| Review Title: | Radiopharmaceuticals for cancer diagnosis and therapy: New targets, new therapies - Alpha-emitters, novel targets |
| Abstract: | Radiopharmaceutical therapy has emerged as a promising approach for the treatment of various cancers. The exploration of novel targets such as tumor-specific antigens, overexpressed receptors, and intracellular biomolecules using antibodies, peptides, or small molecules has expanded the scope of radiopharmaceutical therapy, enabling precise and effective cancer treatment for an increasing number of tumor types. Alpha emitters, characterized by their high linear energy transfer and short path length, offer unique advantages in targeted therapy due to their potent cytotoxicity against cancer cells while sparing healthy tissues. This article reviews recent advancements in identifying novel targets for radiopharmaceutical therapy and applications in utilizing α-emitters for targeted treatment. © Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | unclassified drug; review; drug targeting; cancer diagnosis; radiopharmaceuticals; neoplasm; neoplasms; animal; animals; drug potency; molecular imaging; tumor antigen; cancer therapy; carbonate dehydratase ix; cancer cell; radiopharmaceutical agent; drug cytotoxicity; radioisotope; glycoprotein; theranostics; radiation toxicity; molecularly targeted therapy; fibroblast activation protein; alpha radiation; molecular targeted therapy; alpha particles; linear energy transfer; procedures; humans; human; gastrin releasing peptide receptor; radiopharmaceutical therapy; malignant neoplasm; molecular imaging and therapy; α-emitter |
| Journal Title: | The Cancer Journal |
| Volume: | 30 |
| Issue: | 3 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-05-01 |
| Start Page: | 218 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.1097/ppo.0000000000000720 |
| PUBMED: | 38753757 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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