MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy Journal Article
| Authors: | Sgouros, G.; Roeske, J. C.; McDevitt, M. R.; Palm, S.; Allen, B. J.; Fisher, D. R.; Brill, A. B.; Song, H.; Howell, R. W.; Akabani, G.; Bolch, W. E.; Meredith, R. F.; Wessels, B. W.; Zanzonico, P. B. |
| Article Title: | MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of α-particle emitters for targeted radionuclide therapy |
| Abstract: | The potential of α-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of α-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with α-particle emitters. Although α-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted α-particle emitter therapy and to provide guidance and recommendations for human α-particle emitter dosimetry. Copyright © 2010 by the Society of Nuclear Medicine, Inc. |
| Keywords: | unclassified drug; acute granulocytic leukemia; clinical trial; review; placebo; nonhuman; clinical trials as topic; bone metastasis; radiation dose; rituximab; neoplasms; cell death; cell survival; melanoma; breast cancer; bone marrow; radiotherapy dosage; oxygen; dose-response relationship, radiation; carcinogenesis; prostate cancer; nonhodgkin lymphoma; iodine 131; societies, medical; dosimetry; radiation dose fractionation; neoplasms, radiation-induced; medical research; glioblastoma; ovary carcinoma; radiation-protective agents; radiotherapy planning, computer-assisted; relative biological effectiveness; radioisotope; radioimmunotherapy; relative biologic effectiveness; radioisotopes; radiobiology; myeloid leukemia; alpha radiation; pamphlets; alpha particles; yttrium 90; actinium 225; α-particle emitters; human α-particle emitter dosimetry; targeted α-particle emitter therapy; astatine 211; bismuth 213; polonium; radium 223; microdosimetry |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 51 |
| Issue: | 2 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2010-02-01 |
| Start Page: | 311 |
| End Page: | 328 |
| Language: | English |
| DOI: | 10.2967/jnumed.108.058651 |
| PUBMED: | 20080889 |
| PROVIDER: | scopus |
| PMCID: | PMC5680544 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: JNMEA" - "Source: Scopus" |
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