Alpha radionuclide therapy: Principles and applications to NETs Journal Article
| Author: | Carrasquillo, J. A. |
| Article Title: | Alpha radionuclide therapy: Principles and applications to NETs |
| Abstract: | Radionuclide therapy of neuroendocrine tumors (NETs) including carcinoids, pheochromocytomas, and paragangliomas has an established role. Until recently, therapeutic radiopharmaceuticals for NETs consisted mainly of I-131 MIBG, Y-90/Lu-177/In-111 somatostatin analogs, and bone-seeking radiopharmaceuticals such as Sr-89 and Sm-153. The latter reagents are beta emitters or in the case of In-111, an auger emitter. Alpha emitters have significantly more potent effects and various advantages compared to beta emitters. Although a limited number of studies have been performed with alpha emitters, only a few have targeted NETs. In this presentation, we discuss the rationale for alpha emitters, review existing clinical use of alpha emitters (Bi-213, Ac-225, Pb-212, At-211, Ra-223) in various clinical applications (non-NET), and review existing literature on the preclinical and clinical use of alpha emitters in NETs. © 2017, Springer International Publishing Switzerland. |
| Keywords: | unclassified drug; bone metastasis; cell death; cell cycle; paraganglioma; metastasis; cell growth; oxygen; epidermal growth factor receptor 2; cytotoxicity; dna strand breakage; neuroendocrine tumor; liver metastasis; isotope labeling; neuroblastoma; radiopharmaceutical agent; carcinoid; radioisotope; tumor growth; toxicity; trastuzumab; half life time; pheochromocytoma; blood flow; somatostatin; neuroendocrine; metastatic melanoma; pharmacokinetic parameters; microsphere; actinium 225; linear energy transfer; astatine 211; alpha; ac-225; bismuth 212; beta radiation; bi-213; radium 226; lead 212; ra-223; priority journal; at-211; bi-212; bone matrix; pb-212; thorium; thorium 229 |
| Journal Title: | Contemporary Endocrinology |
| ISSN: | 2523-3785 |
| Publisher: | Humana Press Inc |
| Date Published: | 2017-01-01 |
| Start Page: | 429 |
| End Page: | 445 |
| Language: | English |
| DOI: | 10.1007/978-3-319-46038-3_21 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter 21 in "Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors" Pacak K, Taieb D, eds. (ISBN: 978-3-319-46036-9) -- Export Date: 6 March 2020 -- Source: Scopus |
