Foxo transcription factors in T cell biology and tumor immunity Journal Article

   


Authors: Luo, C. T.; Li, M. O.
Article Title: Foxo transcription factors in T cell biology and tumor immunity
Abstract: The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy. © 2018 Elsevier Ltd
Keywords: t cell; tumor immunology; foxo transcription factor
Journal Title: Seminars in Cancer Biology
Volume: 50
ISSN: 1044-579X
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2018-06-01
Start Page: 13
End Page: 20
Language: English
DOI: 10.1016/j.semcancer.2018.04.006
PROVIDER: scopus
PMCID: PMC5986613
PUBMED: 29684436
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046149528&doi=10.1016%2fj.semcancer.2018.04.006&partnerID=40&md5=9f68b73098066b16031e8628a066521f
Notes: Review -- Export Date: 2 July 2018 -- Source: Scopus
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MSK Authors
  1. Ming Li
    110 Li
  2. Chong Luo
    9 Luo
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