The transcription factor foxo1 controls central-memory CD8+ T cell responses to infection Journal Article

   


Authors: Kim, M.; Ouyang, W.; Liao, W.; Zhang, M.; Li, M.
Article Title: The transcription factor foxo1 controls central-memory CD8+ T cell responses to infection
Abstract: Memory Tcells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced Tcells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ Tcells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector Tcells, memory-precursor Tcells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory Tcell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ Tcell responses to infection. © 2013 Elsevier Inc.
Keywords: controlled study; protein expression; unclassified drug; promoter region; nonhuman; comparative study; cd8+ t lymphocyte; cd8-positive t-lymphocytes; forkhead transcription factors; mouse; phenotype; animals; mice; allele; bone marrow cells; gene expression profiling; cell maturation; animal experiment; animal model; transcription factor; cell differentiation; mice, inbred c57bl; mice, transgenic; granzyme b; lymphocyte activation; cellular immunity; chromatin immunoprecipitation; cell migration; adoptive transfer; green fluorescent proteins; dna microarray; homeostasis; chemokine receptor ccr7; immunologic memory; listeriosis; listeria monocytogenes; t cell transcription factor 1; transcription factor fkhr; memory t lymphocyte; bacterial load; receptors, ccr7; transcription factor tcf7
Journal Title: Immunity
Volume: 39
Issue: 2
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2013-08-22
Start Page: 286
End Page: 297
Language: English
DOI: 10.1016/j.immuni.2013.07.013
PROVIDER: scopus
PUBMED: 23932570
PMCID: PMC3809840
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84882735072&partnerID=40&md5=5fdcf2ab1959166f894023e6b4771563
Notes: --- - "Export Date: 1 October 2013" - "CODEN: IUNIE" - "Source: Scopus"
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MSK Authors
  1. Weiming Ouyang
    9 Ouyang
  2. Ming Li
    111 Li
  3. Myoungjoo Kim
    8 Kim
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