Genome wide mapping of Foxo1 binding-sites in murine T lymphocytes Journal Article
| Authors: | Liao, W.; Ouyang, W.; Zhang, M. Q.; Li, M. O. |
| Article Title: | Genome wide mapping of Foxo1 binding-sites in murine T lymphocytes |
| Abstract: | The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well characterized. In this study, we focused on mapping the genome wide Foxo1-binding sites in naïve CD4+ T cells, CD8+ T cells, and Foxp3+ regulatory T (Treg) cells. By using chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq), we identified Foxo1 binding sites that were shared among or specific to the three T cell populations. Here we describe the experiments, quality controls, as well as the deep sequencing data. Part of the data analysis has been published by Ouyang W et al. in Nature 2012 [1] and Kim MV et al. in Immunity 2013 [2], and the associated data set were uploaded to NCBI Gene Expression Omnibus. |
| Keywords: | controlled study; gene sequence; nonhuman; transcription factor foxp3; cd8+ t lymphocyte; t lymphocyte; quality control; animal cell; mouse; gene expression; cell differentiation; gene mapping; regulatory t lymphocyte; chromatin immunoprecipitation; nucleotide sequence; cd4+ t lymphocyte; data analysis; murinae; binding site; genome; protein dna interaction; transcription factor fkhr; t cell; dna purification; chip-seq; foxo1; male; female; article |
| Journal Title: | Genomics Data |
| Volume: | 2 |
| ISSN: | 2213-5960 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-12-01 |
| Start Page: | 280 |
| End Page: | 281 |
| Language: | English |
| DOI: | 10.1016/j.gdata.2014.08.006 |
| PROVIDER: | scopus |
| PMCID: | PMC4185926 |
| PUBMED: | 25302145 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
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