An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance Journal Article

   

Authors:	Ouyang, W.; Beckett, O.; Flavell, R. A.; Li, M. O.
Article Title:	An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance
Abstract:	Members of the Forkhead box O (Foxo) family of transcription factors are key regulators of cellular responses, but their function in the immune system remains incompletely understood. Here we showed that T cell-specific deletion of Foxo1 gene in mice led to spontaneous T cell activation, effector T cell differentiation, autoantibody production, and the induction of inflammatory bowel disease in a transfer model. In addition, Foxo1 was critical for the maintenance of naive T cells in the peripheral lymphoid organs. Transcriptome analyses of T cells identified Foxo1-regulated genes encoding, among others, cell-surface molecules, signaling proteins, and nuclear factors that control gene expression. Functional studies validated interleukin-7 receptor-α as a Foxo1 target gene essential for Foxo1 maintenance of naive T cells. These findings reveal crucial functions of Foxo1-dependent transcription in control of T cell homeostasis and tolerance. © 2009 Elsevier Inc. All rights reserved.
Keywords:	controlled study; gene deletion; nonhuman; flow cytometry; protein function; t lymphocyte; forkhead transcription factors; t-lymphocytes; protein analysis; mouse; animals; cell cycle proteins; mice; animal tissue; cells, cultured; animal experiment; animal model; nerve tissue proteins; gene expression regulation; cloning, molecular; lymphocyte differentiation; immunological tolerance; immune tolerance; molecular sequence data; enteritis; base sequence; effector cell; autoantibody; homeostasis; molimmuno; transcriptome; t lymphocyte activation; antibody production; skp cullin f-box protein ligases; cellimmuno; interleukin 7 receptor alpha; transcription factor fkhr; immunopathogenesis; receptors, interleukin-7
Journal Title:	Immunity
Volume:	30
Issue:	3
ISSN:	1074-7613
Publisher:	Cell Press
Date Published:	2009-03-20
Start Page:	358
End Page:	371
Language:	English
DOI:	10.1016/j.immuni.2009.02.003
PUBMED:	19285438
PROVIDER:	scopus
PMCID:	PMC2692529
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-62049086102&partnerID=40&md5=39d37b679a46895e0ab764311b7db93d
Notes:	--- - "Cited By (since 1996): 21" - "Export Date: 30 November 2010" - "CODEN: IUNIE" - "Source: Scopus"

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