Foxo: In command of T lymphocyte homeostasis and tolerance Journal Article
| Authors: | Ouyang, W.; Li, M. O. |
| Article Title: | Foxo: In command of T lymphocyte homeostasis and tolerance |
| Abstract: | The forkhead box O (Foxo) family of transcription factors consists of the mammalian orthologs of the Caenorhabditis elegans longevity protein Daf-16, and has an evolutionarily conserved function in the regulation of nutrient sensing and stress responses. Recent studies have shown that Foxo proteins control expression of immune system-specific genes such as Il7ra in naïve T cells and Foxp3 in regulatory T cells, which are crucial regulators of T cell homeostasis and tolerance. These findings reveal that the ancient Foxo pathway has been co-opted to regulate highly specialized T cell activities. The Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state, which is an important prerequisite for the establishment of a functional adaptive immune system. © 2010 Elsevier Ltd. |
| Keywords: | protein expression; protein phosphorylation; review; nonhuman; lymphocyte proliferation; t lymphocyte; cell survival; steady state; immunoregulation; gene expression regulation; lymphocyte differentiation; immunological tolerance; regulatory t lymphocyte; protein transport; immunostimulation; adaptive immunity; homeostasis; thymocyte; t lymphocyte subpopulation; t lymphocyte activation; transcription factor foxo |
| Journal Title: | Trends in Immunology |
| Volume: | 32 |
| Issue: | 1 |
| ISSN: | 1471-4906 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-01-01 |
| Start Page: | 26 |
| End Page: | 33 |
| Language: | English |
| DOI: | 10.1016/j.it.2010.10.005 |
| PROVIDER: | scopus |
| PMCID: | PMC3053075 |
| PUBMED: | 21106439 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: TIRMA" - "Source: Scopus" |
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