High dose chemotherapy with autologous stem cell rescue for patients with medulloblastoma Journal Article

  


Authors: Dunkel, I. J.; Finlay, J. L.
Article Title: High dose chemotherapy with autologous stem cell rescue for patients with medulloblastoma
Abstract: High-dose chemotherapy with autologous stem cell rescue (ASCR) is a promising strategy for patients with poor prognosis cerebellar medulloblastoma. For this strategy to be effective, it must be shown that the medulloblastoma tumor cells are sensitive to the chemotherapeutic agents whose dose-limiting toxicity is hematopoietic, and stem cells must be available that are free of contaminating tumor. Several protocols for high-dose chemotherapy followed by ASCR are presented in this chapter. Initial encouraging evaluations of this technique in patients with recurrent disease has prompted testing of its feasibility in infants and young children. In a reasonably short time, the role of high-dose chemotherapy with ASCR will be determined for subgroups of patients with medulloblastoma.
Keywords: cancer chemotherapy; child; clinical article; child, preschool; disease-free survival; survival rate; busulfan; review; antineoplastic agents; chemotherapy; drug megadose; carboplatin; etoposide; mucosa inflammation; cyclophosphamide; vincristine; stem cell transplantation; hematopoietic stem cell transplantation; age factors; thiotepa; skin exfoliation; infant; tumor recurrence; medulloblastoma; pancytopenia; neurologic disease; cerebellar neoplasms; transplantation, autologous; autologous bone marrow transplantation; liver venoocclusive disease; autologous stem cell rescue; humans; human
Journal Title: Journal of Neuro-Oncology
Volume: 29
Issue: 1
ISSN: 0167-594X
Publisher: Springer  
Date Published: 1996-07-01
Start Page: 69
End Page: 74
Language: English
DOI: 10.1007/bf00165519
PUBMED: 8817417
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030004082&doi=10.1007%2fBF00165519&partnerID=40&md5=388398aa609af950e4904a8ce4256f6a
Notes: Review -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Ira J Dunkel
    371 Dunkel
  2. Jonathan Finlay
    67 Finlay
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