High dose chemotherapy with autologous stem cell rescue in adults with malignant primary brain tumors Journal Article

  


Authors: Abrey, L. E.; Rosenblum, M. K.; Papadopoulos, E.; Childs, B. H.; Finlay, J. L.
Article Title: High dose chemotherapy with autologous stem cell rescue in adults with malignant primary brain tumors
Abstract: High dose chemotherapy (HDCT) with autologous (bone marrow or peripheral blood) stem cell rescue (ASCR) has had success in the treatment of some malignant pediatric brain tumors. We report a series of adults enrolled in one of three HDCT and ASCR protocols for malignant primary brain tumors. Overall toxic mortality was 18%; chemotherapy regimen, tumor type, and prior treatment did not predict transplant-related mortality. Patients over the age of 30 had a higher rate of toxic mortality. Patients with recurrent medulloblastoma had a significant improvement in long-term survival (median: 34 months) as compared with historical reports; two patients with glioblastoma survive beyond four years without progression, but overall, a significant improvement in long-term survival could not be demonstrated for malignant gliomas.
Keywords: adolescent; adult; cancer survival; clinical article; treatment outcome; middle aged; survival analysis; cancer recurrence; salvage therapy; antineoplastic agents; combined modality therapy; chemotherapy; drug megadose; brain tumor; glioma; brain neoplasms; antineoplastic agent; carboplatin; etoposide; stem cell transplantation; hematopoietic stem cell transplantation; dose-response relationship, drug; cancer mortality; carmustine; thiotepa; age; glioblastoma; medulloblastoma; brain cancer; transplantation, autologous; autotransplantation; stem cell rescue; humans; human; male; female; article
Journal Title: Journal of Neuro-Oncology
Volume: 44
Issue: 2
ISSN: 0167-594X
Publisher: Springer  
Date Published: 1999-09-01
Start Page: 147
End Page: 153
Language: English
DOI: 10.1023/a:1006383400353
PUBMED: 10619498
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032794003&partnerID=40&md5=2e884866009ecf3060d3d206f7385046
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Barrett H Childs
    74 Childs
  2. Marc Rosenblum
    424 Rosenblum
  3. Esperanza B Papadopoulos
    415 Papadopoulos
  4. Lauren E Abrey
    278 Abrey
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