The role of high-dose chemotherapy and stem cell rescue in the treatment of malignant brain tumors Conference Paper
| Author: | Finlay, J. L. |
| Title: | The role of high-dose chemotherapy and stem cell rescue in the treatment of malignant brain tumors |
| Conference Title: | Marrow Transplantation in Children: Current Results and Controversies Meeting # 2 |
| Abstract: | The outcome for the majority of children with malignant brain tumors remains poor, despite surgery, irradiation and conventional chemotherapy. In an attempt to improve this poor outcome, strategies utilizing high-dose (potentially myeloablative) chemotherapy with autologous stem cell rescue have been developed. These studies, initially conducted in patients with recurrent brain tumors, have now been extended to patients with newly diagnosed malignant gliomas and to young children with various malignant brain tumors at diagnosis in an attempt to avoid irradiation to the brain. The results of several of these studies are summarized, demonstrating durable disease-free survival for a proportion of patients with recurrent malignant gliomas and medulloblastoma/primitive neuroectodermal tumors, as well as encouraging preliminary data in the newly-diagnosed patients. |
| Keywords: | adult; cancer survival; child; treatment outcome; child, preschool; disease-free survival; busulfan; clinical trial; salvage therapy; drug penetration; conference paper; combined modality therapy; chemotherapy; brain radiation; neurotoxicity; brain tumor; glioma; brain neoplasms; antineoplastic agent; carboplatin; lung toxicity; etoposide; blood toxicity; antineoplastic combined chemotherapy protocols; cyclophosphamide; melphalan; vincristine; stem cell transplantation; hematopoietic stem cell transplantation; carmustine; thiotepa; cranial irradiation; drug fatality; infant; minimal residual disease; feasibility studies; glioblastoma; medulloblastoma; forecasting; ependymoma; platinum derivative; cerebellar neoplasms; neuroectoderm tumor; neuroectodermal tumors; intravenous drug administration; brain tumors; autotransplantation; bone marrow diseases; clinical trials, phase ii; clinical trials, phase i; humans; human; priority journal |
| Journal Title | Bone Marrow Transplantation |
| Volume: | 18 |
| Issue: | Suppl. 3 |
| Conference Dates: | 1995 Jun 1-3 |
| Conference Location: | Hilton Head Island, SC |
| ISBN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1996-12-01 |
| Start Page: | S1 |
| End Page: | S5 |
| Language: | English |
| PUBMED: | 8971398 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 22 November 2017 -- Source: Scopus |
