Validation of nomograms for overall survival, cancer-specific survival, and recurrence in carcinoma of the major salivary glands Journal Article
| Authors: | Hay, A.; Migliacci, J.; Zanoni, D. K.; Patel, S.; Yu, C.; Kattan, M. W.; Ganly, I. |
| Article Title: | Validation of nomograms for overall survival, cancer-specific survival, and recurrence in carcinoma of the major salivary glands |
| Abstract: | Background: The purpose of this study was to investigate the performance of the Memorial Sloan Kettering Cancer Center salivary carcinoma nomograms predicting overall survival, cancer-specific survival, and recurrence with an external validation dataset. Methods: The validation dataset comprised 123 patients treated between 2010 and 2015 at our institution. They were evaluated by assessing discrimination (concordance index [C-index]) and calibration (plotting predicted vs actual probabilities for quintiles). Results: The validation cohort (n = 123) showed some differences to the original cohort (n = 301). The validation cohort had less high-grade cancers (P =.006), less lymphovascular invasion (LVI; P <.001) and shorter follow-up of 19 months versus 45.6 months. Validation showed a C-index of 0.833 (95% confidence interval [CI] 0.758-0.908), 0.807 (95% CI 0.717-0.898), and 0.844 (95% CI 0.768-0.920) for overall survival, cancer-specific survival, and recurrence, respectively. Conclusion: The 3 salivary gland nomograms performed well using a contemporary validation dataset, despite limitations related to sample size, follow-up, and differences in clinical and pathology characteristics between the original and validation cohorts. © 2018 Wiley Periodicals, Inc. |
| Keywords: | survival; recurrence; prediction; nomogram; salivary cancer |
| Journal Title: | Head & Neck |
| Volume: | 40 |
| Issue: | 5 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2018-05-01 |
| Start Page: | 1008 |
| End Page: | 1015 |
| Language: | English |
| DOI: | 10.1002/hed.25079 |
| PROVIDER: | scopus |
| PMCID: | PMC5912956 |
| PUBMED: | 29389040 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2018 -- Source: Scopus |
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