Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy Journal Article


Authors: Apolo, A. B.; Ostrovnaya, I.; Halabi, S.; Iasonos, A.; Philips, G. K.; Rosenberg, J. E.; Riches, J.; Small, E. J.; Milowsky, M. I.; Bajorin, D. F.
Article Title: Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy
Abstract: A prognostic model that predicts overall survival (OS) for metastatic urothelial cancer (MetUC) patients treated with cisplatin-based chemotherapy was developed, validated, and compared with a commonly used Memorial Sloan-Kettering Cancer Center (MSKCC) risk-score model. Data from 7 protocols that enrolled 308 patients with MetUC were pooled. An external multi-institutional dataset was used to validate the model. The primary measurement of predictive discrimination was Harrell's c-index, computed with 95% confidence interval (CI). The final model included four pretreatment variables to predict OS: visceral metastases, albumin, performance status, and hemoglobin. The Harrell's c-index was 0.67 for the four-variable model and 0.64 for the MSKCC risk-score model, with a prediction improvement for OS (the U statistic and its standard deviation were used to calculate the two-sided P =. 002). In the validation cohort, the c-indices for the four-variable and the MSKCC risk-score models were 0.63 (95% CI = 0.56 to 0.69) and 0.58 (95% CI = 0.52 to 0.65), respectively, with superiority of the four-variable model compared with the MSKCC risk-score model for OS (the U statistic and its standard deviation were used to calculate the two-sided P =. 02). © 2013 The Author.
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 105
Issue: 7
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 2013-04-03
Start Page: 499
End Page: 503
Language: English
PROVIDER: scopus
PUBMED: 23411591
DOI: 10.1093/jnci/djt015
PMCID: PMC3691944
DOI/URL:
Notes: --- - "Export Date: 1 May 2013" - "CODEN: JNCIA" - ":doi 10.1093/jnci/djt015" - "Source: Scopus"
Altmetric
Citation Impact
MSK Authors
  1. Dean Bajorin
    637 Bajorin
  2. Andrea Borghese Apolo
    7 Apolo
  3. Alexia Elia Iasonos
    319 Iasonos
  4. Jamie C Riches
    27 Riches
  5. Jonathan Eric Rosenberg
    461 Rosenberg