Postoperative nomograms predictive of survival after surgical management of malignant tumors of the major salivary glands Journal Article

Authors: Ali, S.; Palmer, F. L.; Yu, C.; DiLorenzo, M.; Shah, J. P.; Kattan, M. W.; Patel, S. G.; Ganly, I.
Article Title: Postoperative nomograms predictive of survival after surgical management of malignant tumors of the major salivary glands
Abstract: Objectives: The objective of this study was to create a nomogram predictive of survival in salivary gland cancer. Methods: Clinical, tumor, and treatment characteristics were collected for 301 patients who underwent surgery for salivary gland cancer between 1985 and 2009 at Memorial Sloan Kettering Cancer Centre. Factors predictive of overall survival (OS) and cancer-specific survival (CSS) were determined by univariate analysis. Cox risk regression was used to model OS data. Competing risks regression was used for cancer-specific death. Deaths from other causes were treated as competing risks for cancer-specific death. Predictive nomograms for OS and CSS were then created using stepdown method to select predictors of outcome. Results: The median age was 62 (range 9-89) years. There were 156 (52 %) males and 145 (48 %) females. Five variables predictive for OS (age, clinical T4 stage, histological grade, perineural invasion, and tumor dimension) were used to generate a parsimonious model, and a nomogram was created to predict 10-year survival probability. The concordance index (CI) for this nomogram was 0.809. Five variables predictive for CSS (histological grade, perineural invasion, clinical T4 stage, positive nodal status, and status of margins) were used to generate a second nomogram predicting CSS. This nomogram had a CI of 0.856. Both nomograms were validated internally by assessing discrimination and calibration. Conclusions: We have developed the first nomograms to predict prognosis in an individual patient with salivary gland cancer. © 2013 Society of Surgical Oncology.
Keywords: adolescent; adult; child; school child; treatment outcome; aged; middle aged; young adult; major clinical study; postoperative care; calibration; cancer specific survival; salivary gland carcinoma; nomogram; perineural invasion; predictive value; very elderly; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 21
Issue: 2
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2014-02-01
Start Page: 637
End Page: 642
Language: English
DOI: 10.1245/s10434-013-3321-y
PROVIDER: scopus
PUBMED: 24132626
Notes: Export Date: 2 April 2014 -- CODEN: ASONF -- Source: Scopus
Citation Impact
MSK Authors
  1. Snehal G Patel
    342 Patel
  2. Ian Ganly
    313 Ganly
  3. Safina Ali
    11 Ali
  4. Jatin P Shah
    643 Shah
  5. Frank Palmer
    82 Palmer