Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features: A case report Journal Article
| Authors: | Corrias, G.; Horvat, N.; Monti, S.; Basturk, O.; Lin, O.; Saba, L.; Bodei, L.; Reidy, D. L.; Mannelli, L. |
| Article Title: | Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features: A case report |
| Abstract: | Rationale: Glucagonoma is an uncommon disease but it has been associated with a pattern of symptoms defined as glucagonoma syndrome. These symptoms, if promptly recognized, could help to speed up the diagnosing process. Patient concerns: We report a case of a 68-year-old woman with a pancreatic glucagonoma. Her symptoms at the onset were typical of the glucagonoma syndrome. Diagnoses: After a significant weight loss, she underwent a computer tomography scan of the abdomen, which showed a hypervascular lesion of the tail of the pancreas and hypervascular lesions of the liver. An ultrasound guided biopsy was performed and pathology was consistent with glucagonoma. Her blood glucagon levels were elevated. Outcomes: She was treated with chemotherapy and somatostatin analogs. After 4 years, the disease had a malignant transformation, and metastases suddenly started to grow up. She stopped being responsive to treatment and eventually passed away. Lessons: Due to its rarity, clinical diagnosis is challenging and generally it comes after a long interval since the onset of symptoms. Awareness of physicians and dermatologists of the characteristic necrolytic migratory erythema, and of the other symptoms, often leads to early diagnosis. Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. |
| Keywords: | cancer chemotherapy; clinical article; treatment response; aged; clinical feature; fatigue; case report; fluorouracil; diarrhea; nuclear magnetic resonance imaging; dacarbazine; computer assisted tomography; multiple cycle treatment; weight reduction; abdominal pain; dyspnea; alkaline phosphatase; patient care; early diagnosis; laboratory test; contrast enhancement; hepatomegaly; diabetes mellitus; erythema; physical examination; liver function test; gastroesophageal reflux; malignant transformation; chromogranin; hyperlipidemia; tumor diagnosis; tachycardia; pentetreotide in 111; neuroendocrine tumors; multidetector computed tomography; cytokeratin ae1; cytokeratin ae3; synaptophysin; medical history; dermatologist; mucosal dryness; irritable colon; glucagonoma; glucagon; next generation sequencing; human; female; priority journal; article; octreoscan; single photon emission computed tomography-computed tomography; somatostatin receptor imaging; glucagon blood level; necrolytic migratory erythema |
| Journal Title: | Medicine |
| Volume: | 96 |
| Issue: | 50 |
| ISSN: | 0025-7974 |
| Publisher: | Wolters Kluwer Health, Inc |
| Date Published: | 2017-12-01 |
| Start Page: | e9252 |
| Language: | English |
| DOI: | 10.1097/md.0000000000009252 |
| PROVIDER: | scopus |
| PUBMED: | 29390362 |
| PMCID: | PMC5815774 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2018 -- Source: Scopus |
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