Recurrent metastatic neuroblastoma followed by myelodysplastic syndrome: Possible leukemogenic role of temozolomide Journal Article

   

Authors:	Kushner, B. H.; LaQuaglia, M. P.; Kramer, K.; Modak, S.; Cheung, N. K. V.
Article Title:	Recurrent metastatic neuroblastoma followed by myelodysplastic syndrome: Possible leukemogenic role of temozolomide
Abstract:	An 8-year old child had a pelvic MYCN-nonamplified neuroblastoma (NB) with retroperitoneal nodal extension. Multi-modality therapy achieved complete remission (CR). Small recurrences confined to left supraclavicular nodes were treated with surgery alone at 4.9, 6.5, 7.5, 9.5, and 12.9 years from diagnosis. Monitoring through 12 months after the last resection showed CR. When she returned 34 months later (16.8 years from diagnosis), she had massive disease in the left neck and upper trunk, without osteomedullary metastases. Salvage therapy featured 11 cycles of temozolomide. She developed myelodysplastic syndrome with 45,XX,der(7)t(7;21) (p15;q11),-21 at age 24 and refused treatment; 19 months later she was transfusion-dependent but her NB remained in CR. © 2008 Wiley-Liss, Inc.
Keywords:	adolescent; adult; child; school child; treatment outcome; thalidomide; case report; salvage therapy; cisplatin; doxorubicin; multimodality cancer therapy; combined modality therapy; temozolomide; topotecan; recurrent cancer; lymph node metastasis; paraaortic lymph node; treatment indication; carboplatin; dacarbazine; multiple cycle treatment; etoposide; blood toxicity; thrombocytopenia; recurrence; cyclophosphamide; vincristine; patient monitoring; ifosfamide; cell transformation, neoplastic; irinotecan; oncogene; cancer regression; myelodysplastic syndrome; neuroblastoma; celecoxib; leukemogenesis; neoplasm metastasis; blood transfusion; alkylating agents; treatment refusal; chromosomal aberrations; topoisomerase ii inhibitors; myelodysplastic syndromes; mycn gene
Journal Title:	Pediatric Blood and Cancer
Volume:	51
Issue:	4
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2008-10-01
Start Page:	552
End Page:	554
Language:	English
DOI:	10.1002/pbc.21658
PUBMED:	18570300
PROVIDER:	scopus
PMCID:	PMC4010138
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-50249103183&partnerID=40&md5=84b71620a6320941f0358398e237386d
Notes:	--- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: PBCEA" - "Source: Scopus"

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