Case report of unusual leukoencephalopathy preceding primary CNS lymphoma Journal Article
| Authors: | Brecher, K.; Hochberg, F. H.; Louis, D. N.; de la Monte, S.; Riskind, P. |
| Article Title: | Case report of unusual leukoencephalopathy preceding primary CNS lymphoma |
| Abstract: | A previously healthy 35 year old woman presented with bilateral uveitus associated with multiple, evolving, non-enhancing white matter lesions consistent with a progressive leukoencephalopathy such as multiple sclerosis. Thirty months after her initial presentation, she was diagnosed with primary CNS lymphoma and died 14 months later. The unusual clinical course preceding the diagnosis suggests that a demyelinating disease may have preceded, and possibly heralded, the development of primary CNS lymphoma. Cases of "sentinel lesions" heralding the diagnosis of primary CNS lymphoma have been reported, and this case further corroborates such instances and raises further issues regarding possible neoplastic transformation occurring in inflammatory diseases such as multiple sclerosis. |
| Keywords: | adult; case report; nuclear magnetic resonance imaging; brain tumor; brain neoplasms; magnetic resonance imaging; pathology; central nervous system; lymphoma; multiple sclerosis; demyelinating disease; humans; human; female; article; primary lymphoma |
| Journal Title: | Journal of Neurology Neurosurgery and Psychiatry |
| Volume: | 65 |
| Issue: | 6 |
| ISSN: | 0022-3050 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 1998-12-01 |
| Start Page: | 917 |
| End Page: | 920 |
| Language: | English |
| PUBMED: | 9854972 |
| PROVIDER: | scopus |
| PMCID: | PMC2170412 |
| DOI: | 10.1136/jnnp.65.6.917 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
