Circulating adiponectin levels differ between patients with multiple myeloma and its precursor disease Journal Article


Authors: Hofmann, J. N.; Mailankody, S.; Korde, N.; Wang, Y.; Tageja, N.; Costello, R.; Zingone, A.; Hultcrantz, M.; Pollak, M. N.; Purdue, M. P.; Landgren, O.
Article Title: Circulating adiponectin levels differ between patients with multiple myeloma and its precursor disease
Abstract: Objective: An increased risk of multiple myeloma (MM) has been observed among individuals with low prediagnostic circulating levels of adiponectin, a metabolic hormone that is typically underexpressed among those with overweight or obesity. To assess whether adiponectin may influence myeloma development or progression to frank MM, circulating adiponectin levels were compared across patients with different stages of MM and its precursor, monoclonal gammopathy of undetermined significance (MGUS). Methods: Adiponectin was measured in 213 patients with MGUS, smoldering MM, or fully developed MM. Differences in adiponectin levels across patient groups were assessed using multivariate linear regression. Results: Relative to MGUS patients, adiponectin levels were statistically significantly lower among those with smoldering and fully developed MM, both overall (16%-20% decrease; P = 0.048) and among those with IgG/IgA isotypes (26%-28% decrease; P = 0.004). Among MGUS patients, adiponectin levels were significantly lower for those with the higher-risk IgM isotype compared with those who had IgG/IgA isotypes (42% decrease; P = 0.036). Conclusions: The findings of this study, the largest to investigate adiponectin levels in patients with different stages of MM and the first to evaluate associations with clinical characteristics, suggest that reduced expression of adiponectin may be associated with progression from MGUS to MM. © 2017 The Obesity Society
Journal Title: Obesity
Volume: 25
Issue: 8
ISSN: 1930-7381
Publisher: Wiley Blackwell  
Date Published: 2017-08-01
Start Page: 1317
End Page: 1320
Language: English
DOI: 10.1002/oby.21894
PROVIDER: scopus
PUBMED: 28602036
PMCID: PMC5611818
DOI/URL:
Notes: Article -- Export Date: 1 August 2017 -- Source: Scopus
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MSK Authors
  1. Carl Ola Landgren
    306 Landgren
  2. Neha Sanat Korde
    95 Korde