Low levels of circulating adiponectin are associated with multiple myeloma risk in overweight and obese individuals Journal Article

Authors: Hofmann, J. N.; Birmann, B. M.; Teras, L. R.; Pfeiffer, R. M.; Wang, Y.; Albanes, D.; Baris, D.; Colditz, G. A.; De Roos, A. J.; Giles, G. G.; Hosgood, H. D.; Lan, Q.; Landgren, O.; Liao, L. M.; Rothman, N.; Weinstein, S. J.; Pollak, M. N.; Neuhouser, M. L.; Purdue, M. P.
Article Title: Low levels of circulating adiponectin are associated with multiple myeloma risk in overweight and obese individuals
Abstract: The association between obesity and multiple myeloma risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals. To prospectively evaluate multiple myeloma risk in relation to adiponectin levels overall and stratified by body mass index and other characteristics, we conducted a pooled investigation of pre-diagnosed peripheral blood samples from 624 multiple myeloma cases and 1,246 individually matched controls from seven cohorts participating in the Multiple Myeloma Cohort Consortium. Analysis of circulating analyte levels measured by ELISA revealed that higher total adiponectin levels were associated with reduced multiple myeloma risk overall [highest quartile vs. lowest: OR, 0.64; 95% confidence interval (CI) 0.47-0.85; Ptrend = 0.001]. This association was apparent among cases diagnosed six or more years after blood collection (OR, 0.60; 95% CI, 0.40-0.90; Ptrend = 0.004) and was similar in magnitude for men and women (OR, 0.59 and 0.66, respectively). Interestingly, we observed strong associations among subjects who were overweight (OR, 0.41; 95% CI, 0.26-0.65) or obese (OR, 0.41; 95% CI, 0.17-0.98) but not among those with normal weight (OR, 1.20; 95% CI, 0.73-2.00; overweight/obese vs. normal weight, Pinteraction = 0.04). Our findings provide the strongest epidemiologic evidence to date that adiponectin protects against multiple myeloma development, particularly among overweight and obese individuals, and offer a method for risk assessment in this susceptible population of heavier patients. © 2016 AACR.
Journal Title: Cancer Research
Volume: 76
Issue: 7
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 2016-04-01
Start Page: 1935
End Page: 1941
Language: English
DOI: 10.1158/0008-5472.can-15-2406
PROVIDER: scopus
PUBMED: 26921332
PMCID: PMC4878138
Notes: Article -- Export Date: 2 May 2016 -- Source: Scopus
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  1. Carl Ola Landgren
    175 Landgren