Host-related immunodeficiency in the development of multiple myeloma Journal Article


Authors: Dosani, T.; Mailankody, S.; Korde, N.; Manasanch, E.; Bhutani, M.; Tageja, N.; Roschewski, M.; Kwok, M.; Kazandjian, D.; Costello, R.; Burton, D.; Zhang, Y.; Liewehr, D.; Steinberg, S. M.; Maric, I.; Landgren, O.
Article Title: Host-related immunodeficiency in the development of multiple myeloma
Abstract: Host-related immunodeficiency is known to play a role in the development of multiple myeloma (MM) from its precursor conditions (monoclonal gammopathy of undetermined significance, MGUS, smoldering multiple myeloma, SMM). In order to understand the underlying immune changes in this process, we characterized immune patterns from MGUS to SMM to MM. We further sought to identify potential novel immune biomarkers that may predict progression of SMM to MM. We characterized patterns of circulating lymphocytes in 181 patients using multiparametric flow cytometry. We found decreased B- (p =.0003), increased T- (p =.037) and unaltered NK cell proportions from MGUS to SMM to MM. To gain insights into functional variability, we further characterized immunophenotypic lymphocyte subsets, which uncovered differences in CD57 subsets. Specifically, we found that SMM patients who eventually progressed to MM showed decreased proportions of CD57-CD56 + (p =.0061) and CD57-CD16 + (p =.035) lymphocyte subsets. We thus report novel data characterizing the nature of host-related immunodeficiency in the development of MM. We show sequential changes in lymphocyte subsets from MGUS to SMM to MM. We further suggest that CD57 subsets may serve as potential markers of progression from SMM to MM. Our findings support the study of lymphocyte subsets in the search for immune biomarkers. Such markers could provide clinical guidance in managing myeloma precursor disease. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: immunology; tumor markers; cancer biology; neoplasia myeloma and other plasma cell dyscrasias
Journal Title: Leukemia and Lymphoma
Volume: 59
Issue: 5
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2018-01-01
Start Page: 1127
End Page: 1132
Language: English
DOI: 10.1080/10428194.2017.1361026
PROVIDER: scopus
PUBMED: 28792255
DOI/URL:
Notes: Article -- Export Date: 2 April 2018 -- Source: Scopus
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MSK Authors
  1. Carl Ola Landgren
    175 Landgren
  2. Neha Sanat Korde
    56 Korde