Expression of the IL-6 receptor alpha-chain (CD126) in normal and abnormal plasma cells in monoclonal gammopathy of undetermined significance and smoldering myeloma Journal Article


Authors: Salem, D. A. R.; Korde, N.; Venzon, D. J.; Liewehr, D. J.; Maric, I.; Calvo, K. R.; Braylan, R.; Tembhare, P. R.; Yuan, C. M.; Landgren, C. O.; Stetler-Stevenson, M.
Article Title: Expression of the IL-6 receptor alpha-chain (CD126) in normal and abnormal plasma cells in monoclonal gammopathy of undetermined significance and smoldering myeloma
Abstract: IL-6 activity in normal plasma cells (nPCs) and abnormal plasma cells (aPCs) is CD126 (subunit of IL-6 receptor) dependent. We quantified CD126 expression on nPCs and aPCs in monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma (SMM), and multiple myeloma (MM). CD126 was detected on all nPCs and aPCs indicating that CD126 does not have diagnostic utility. CD126 expression was higher in aPCs than in nPCs in 85% SMM but only 41% MGUS and there was evidence that CD126 was higher in aPCs than nPCs in the SMM (p =.048) but not MGUS (p =.96) patients. There is also a greater association between nPC and aPC CD126 expression in low risk MGUS than observed in high risk MGUS and SMM, suggesting normal regulation of CD126 decreases with disease progression. Future studies need to elucidate the role of bone marrow milieu versus escape from normal CD126 regulation in malignant transformation of clonal plasma cells. © 2017 US Government author.
Keywords: flow cytometry; mgus; smoldering myeloma; il-6 receptor; cd126
Journal Title: Leukemia and Lymphoma
Volume: 59
Issue: 1
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2018-01-01
Start Page: 178
End Page: 186
Language: English
DOI: 10.1080/10428194.2017.1321746
PROVIDER: scopus
PUBMED: 28540748
DOI/URL:
Notes: Article -- Export Date: 4 October 2017 -- Source: Scopus
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MSK Authors
  1. Carl Ola Landgren
    165 Landgren
  2. Neha Sanat Korde
    53 Korde