Bloodstream infections in patients with chronic lymphocytic leukemia: A longitudinal single-center study Journal Article


Authors: Kjellander, C.; Björkholm, M.; Källman, O.; Giske, C. G.; Weibull, C. E.; Löve, T. J.; Landgren, O.; Kristinsson, S. Y.
Article Title: Bloodstream infections in patients with chronic lymphocytic leukemia: A longitudinal single-center study
Abstract: Infectious complications in chronic lymphocytic leukemia (CLL) represent a major cause of morbidity and mortality. The aim of the study was to investigate temporal trends in bloodstream infections (BSIs) among patients with CLL. Individuals with blood cultures were linked to Swedish Cancer Registry and divided into three time periods (1988–1993, 1994–1999, and 2000–2006) according to year of CLL diagnosis. CLL patients (n = 275) with 1092 blood culture episodes were identified and linked to the nationwide Cause of Death Registry and Swedish Patient Registry (to retrieve information on splenectomies). The most common causes of BSI among CLL patients were Escherichia coli (11/43, 15/78, and 9/33), Streptococcus pneumoniae (7/43, 13/78, and 6/33), Pseudomonas aeruginosa (2/43, 8/78, and 3/33), Staphylococcus aureus (1/43, 6/78, and 6/33), and Viridans streptococci (5/43, 6/78, and 2/33). Coagulase-negative staphylococci was the most frequent microorganism found in blood cultures (22/70, 23/106, and 5/41, respectively) but is a frequent contaminant. Based on the largest study to date on BSI in CLL patients, we found a stable proportion of Gram-positive to Gram-negative bacteria and no temporal change of distribution was observed for BSIs 1988–2006. © 2016, Springer-Verlag Berlin Heidelberg.
Keywords: adult; aged; major clinical study; splenectomy; cancer diagnosis; sensitivity analysis; cause of death; escherichia coli; cancer registry; staphylococcus aureus; bloodstream infection; chronic lymphatic leukemia; streptococcus pneumoniae; longitudinal study; chronic lymphocytic leukemia; pseudomonas aeruginosa; blood culture; coagulase negative staphylococcus; infections; alpha hemolytic streptococcus; prognosis; human; male; female; priority journal; article; bloodstream infections
Journal Title: Annals of Hematology
Volume: 95
Issue: 6
ISSN: 0939-5555
Publisher: Springer  
Date Published: 2016-05-01
Start Page: 871
End Page: 879
Language: English
DOI: 10.1007/s00277-016-2643-9
PUBMED: 26976017
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 3 July 2017 -- Source: Scopus
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  1. Carl Ola Landgren
    334 Landgren