Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation Journal Article

   


Authors: Ustun, C.; Young, J. A. H.; Papanicolaou, G. A.; Kim, S.; Ahn, K. W.; Chen, M.; Abdel-Azim, H.; Aljurf, M.; Beitinjaneh, A.; Brown, V.; Cerny, J.; Chhabra, S.; Kharfan-Dabaja, M. A.; Dahi, P. B.; Daly, A.; Dandoy, C. E.; Dvorak, C. C.; Freytes, C. O.; Hashmi, S.; Lazarus, H.; Ljungman, P.; Nishihori, T.; Page, K.; Pingali, S. R. K.; Saad, A.; Savani, B. N.; Weisdorf, D.; Williams, K.; Wirk, B.; Auletta, J. J.; Lindemans, C. A.; Komanduri, K.; Riches, M.
Article Title: Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation
Abstract: We analyzed CIBMTR data to evaluate the incidence of non-relapse mortality (NRM) and association with overall survival (OS) for bacterial blood stream infections (BSIs) occurring within 100 days of alloHCT in 2 different phases: pre-/peri-engraftment (BSI very early phase, BSI-VEP) and BSI post-engraftment (BSI occurring between 2 weeks after engraftment and day 100, late early phase, BSI-LEP). Of the 7128 alloHCT patients, 2656 (37%) had ≥1 BSI by day 100. BSI-VEP, BSI-LEP, and BSI-Both constituted 56% (n = 1492), 31% (n = 824), and 13% (n = 340) of total BSI, respectively. Starting in 2009, we observed a gradual decline in BSI incidence through 2012 (61–48%). Patients with BSI-VEP were more likely to receive a myeloablative conditioning (MAC) regimen with total body irradiation (TBI). NRM was significantly higher in patients with any BSI (RR 1.82 95% CI 1.63–2.04 for BSI-VEP, RR 2.46, 95% CI 2.05–2.96 for BSI-LEP, and RR 2.29, 95% CI 1.87–2.81 for BSI-Both) compared with those without BSI. OS was significantly lower in patients with any BSI compared with patients without BSI (RR 1.36, 95% CI 1.26–1.47 for BSI-VEP; RR 1.83, 95% CI 1.58–2.12 for BSI-LEP: RR 1.66, 95% CI 1.43–1.94 for BSI-Both). BSIs within day 100 after alloHCT are common and remain a risk factor for mortality. © 2018, Springer Nature Limited.
Journal Title: Bone Marrow Transplantation
Volume: 54
Issue: 8
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2019-08-01
Start Page: 1254
End Page: 1265
Language: English
DOI: 10.1038/s41409-018-0401-4
PUBMED: 30546070
PROVIDER: scopus
PMCID: PMC6565512
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058447470&doi=10.1038%2fs41409-018-0401-4&partnerID=40&md5=27ba17e4b7d91e3a5ca12bf1b3b8f549
Notes: Article -- Export Date: 30 August 2019 -- Source: Scopus
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MSK Authors
  1. Genovefa A Papanicolaou
    238 Papanicolaou
  2. Parastoo Bahrami Dahi
    304 Dahi
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