Origins of bloodstream infections following fecal microbiota transplantation: A strain-level analysis Journal Article
| Authors: | Eshel, A.; Sharon, I.; Nagler, A.; Bomze, D.; Danylesko, I.; Fein, J. A.; Geva, M.; Henig, I.; Shimoni, A.; Zuckerman, T.; Youngster, I.; Koren, O.; Shouval, R. |
| Article Title: | Origins of bloodstream infections following fecal microbiota transplantation: A strain-level analysis |
| Abstract: | We observed high rates of bloodstream infections (BSIs) following fecal microbiota transplantation (FMT) for graft-versus-host-disease (33 events in 22 patients). To trace the BSIs' origin, we applied a metagenomic bioinformatic pipeline screening donor and recipient stool samples for bacteremia-causing strains in 13 cases. Offending strains were not detected in FMT donations. Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii could be detected in stool samples before emerging in the blood. In this largest report of BSIs post-FMT, we present an approach that may be applicable for evaluating BSI origin following microbiota-based interventions. Our findings support FMT safety in immunocompromised patients but do not rule out FMT as an inducer of bacterial translocation. © 2022 American Society of Hematology. All rights reserved. |
| Keywords: | clinical article; nonhuman; bacterial strain; donor; screening; escherichia coli; patient safety; bacteremia; bloodstream infection; bioinformatics; feces analysis; acinetobacter baumannii; immunocompromised patient; enterococcus faecium; recipient; pseudomonas aeruginosa; metagenomics; bacterial translocation; human; article; fecal microbiota transplantation |
| Journal Title: | Blood Advances |
| Volume: | 6 |
| Issue: | 2 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2022-01-25 |
| Start Page: | 568 |
| End Page: | 573 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2021005110 |
| PUBMED: | 34644375 |
| PROVIDER: | scopus |
| PMCID: | PMC8791595 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2022 -- Source: Scopus |
