Running a PDX core laboratory or a PDX support program Book Section
| Authors: | Krivtsov, A.; Mattar, M.; Uthamanthil, R. K.; de Stanchina, E. |
| Editors: | Uthamanthil, R.; Tinkey, P; de Stanchina, E. |
| Article/Chapter Title: | Running a PDX core laboratory or a PDX support program |
| Abstract: | Patient-derived xenografts (PDXs) are a powerful technology with the potential to unlock key mechanisms of disease for a variety of difficult-to-treat cancers and cancers with no applicable laboratory models. While individual laboratories can excel at establishing such models, there are procedural, technical, and financial challenges which present serious obstacles for established investigators as well as new investigators without prior experience with PDX models. Therefore, for some institutions, it is preferable to designate a centralized "PDX Core" to streamline the workflow that is required for the success of such a program and make it more cost-effective. Here we describe the key infrastructural components of a successful academic PDX program, underscore the need for well-established procedures and standardized protocols, and discuss cost management strategies. © 2017 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; biobank; mouse hospital; pdx core; pdx database; pdx program |
| Book Title: | Patient Derived Tumor Xenograft Models: Promise, Potential and Practice |
| ISBN: | 978-0-12-804010-2 |
| Publisher: | Academic Press, Elsevier Inc |
| Publication Place: | London, UK |
| Date Published: | 2017-01-01 |
| Start Page: | 161 |
| End Page: | 172 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-804010-2.00012-6 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Section II Chapter 6 -- Export Date: 3 July 2017 -- Source: Scopus |
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