Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis Journal Article
| Authors: | Murphy, M.; Bernard, E. M.; Ishimaru, T.; Armstrong, D. |
| Article Title: | Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis |
| Abstract: | Voriconazole, a new azole antifungal agent, showed potent activity against clinical isolates of Aspergillus spp. in vitro. For A. fumigatus, the MIC range was <0.03 to 0.5 mu g/ml and the MIC at which 90% of isolates are inhibited was 0.25 mu g/ml. In an experimental model of invasive pulmonary aspergillosis which mimics infection in humans, oral voriconazole at dosages of 30 mg/kg of body weight per day significantly delayed or prevented mortality. |
| Keywords: | bioassay; therapy; antifungal; itraconazole; fungal-infections; mycoses; aerosol; rat model |
| Journal Title: | Antimicrobial Agents and Chemotherapy |
| Volume: | 41 |
| Issue: | 3 |
| ISSN: | 0066-4804 |
| Publisher: | American Society for Microbiology |
| Date Published: | 1997-03-01 |
| Start Page: | 696 |
| End Page: | 698 |
| Language: | English |
| ACCESSION: | WOS:A1997WL11100035 |
| PROVIDER: | wos |
| PMCID: | PMC163774 |
| PUBMED: | 9056016 |
| Notes: | Article -- Source: Wos |
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