In vitro activity of ceftazidime-avibactam against carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates Journal Article

   


Authors: Yu, F.; Lv, J.; Niu, S.; Du, H.; Tang, Y. W.; Bonomo, R. A.; Kreiswirth, B. N.; Chen, L.
Article Title: In vitro activity of ceftazidime-avibactam against carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates
Abstract: Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) strains have emerged while antimicrobial treatment options remain limited. Herein, we tested the in vitro activity of ceftazidime-avibactam and other comparator antibiotics against 65 CR-hvKp isolates. Ceftazidime-avibactam, colistin, and tigecycline are highly active in vitro against CR-hvKp isolates (MIC90, 1 g/ml), including K. pneumoniae carbapenemase 2 (KPC-2)-producing ST11 CR-hvKp. On the basis of previous clinical experience and the in vitro data presented herein, we posit that ceftazidime-avibactam is a therapeutic option against CR-hvKp infections. Copyright © 2018 American Society for Microbiology. All Rights Reserved.
Keywords: controlled study; unclassified drug; drug efficacy; nonhuman; polymerase chain reaction; in vitro study; bacterial strain; bacterial virulence; antibiotic resistance; ciprofloxacin; bacterium isolate; gentamicin; cotrimoxazole; levofloxacin; ceftriaxone; piperacillin plus tazobactam; bacterial gene; colistin; susceptibility; antibacterial activity; comparative effectiveness; cefepime; bacterial enzyme; ceftazidime; meropenem; klebsiella pneumoniae; imipenem; amikacin; ertapenem; sanger sequencing; priority journal; article; tigecycline; aztreonam; avibactam plus ceftazidime; carbapenemase; ceftazidime-avibactam; carbapenem resistance; hypervirulent klebsiella pneumoniae; beta lactamase ctx m; beta lactamase shv; beta lactamase tem 1; doripenem; klebsiella pneumoniae carbapenemase 2; carbapenem resistant and hypervirulent klebsiella pneumoniae; iuta gene; mic50; mic90; multilocus sequence typing; rmpa gene
Journal Title: Antimicrobial Agents and Chemotherapy
Volume: 62
Issue: 8
ISSN: 0066-4804
Publisher: American Society for Microbiology  
Date Published: 2018-08-01
Start Page: e01031-18
Language: English
DOI: 10.1128/AAC.01031-18
PROVIDER: scopus
PMCID: PMC6105775
PUBMED: 29891605
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052024457&doi=10.1128%2fAAC.01031-18&partnerID=40&md5=739845e04aea1cd809cd8888fcce8612
Notes: Article -- Export Date: 1 October 2018 -- Source: Scopus
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  1. Yi-Wei Tang
    188 Tang
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