Sumoylation and the DNA damage response Journal Article
| Authors: | Cremona, C. A.; Sarangi, P.; Zhao, X. |
| Article Title: | Sumoylation and the DNA damage response |
| Abstract: | The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response. © 2012 by the authors; licensee MDPI, Basel, Switzerland. |
| Keywords: | signal transduction; protein phosphorylation; review; nonhuman; ubiquitin; dna replication; dna damage; homologous recombination; protein interaction; protein processing; saccharomyces cerevisiae; dna damage response; double stranded dna break; oxidative stress; molecular interaction; ubiquitin protein ligase e3; cell cycle regulation; sumo protein; sumoylation; histone h2ax; rad52 protein; dna damage checkpoint; genome integrity; dna integration |
| Journal Title: | Biomolecules |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 2218-273X |
| Publisher: | MDPI |
| Date Published: | 2012-09-04 |
| Start Page: | 376 |
| End Page: | 388 |
| Language: | English |
| DOI: | 10.3390/biom2030376 |
| PROVIDER: | scopus |
| PMCID: | PMC4030838 |
| PUBMED: | 24926426 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 May 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work