Abstract: |
Obesity is a major health problem affecting more than one third of adult Americans. It is increasing in prevalence and is associated with many comorbid conditions including cardiovascular disease, certain forms of cancer, diabetes mellitus, degenerative disease of the weight-bearing joints, and sleep apnea. Our improved understanding of the molecular mechanisms underlying obesity has encouraged the use of currently available antiobesity drugs, even though the long-term safety and efficacy of these drugs have not been completely examined. Here we review the currently approved medications for treating obesity in the United States, emphasizing appropriate uses and side effects. Combinations of existing medications and the development of new pharmacotherapeutic approaches are outlined. Medications for the treatment of obesity should be used only under physician supervision as an adjunct to a program of behavioral change directed toward improving diet and increasing physical activity. The future of the pharmacologie treatment of obesity is particularly promising. © 1997 Rapid Science Publishers. |