The role of obesity and inflammation in breast cancer recurrence Review
| Authors: | Chew, S. M.; Liu, B.; Shen, S.; Iyengar, N. M. |
| Review Title: | The role of obesity and inflammation in breast cancer recurrence |
| Abstract: | Purpose of review: The purpose of this study is to summarize the latest findings regarding the impact of obesity and inflammation on breast cancer recurrence risk. Recent Findings: Obesity is a risk factor for breast cancer recurrence and cancer-specific mortality. Biologic mechanisms that drive this association vary by tumor subtype and include a dysfunctional tumor microenvironment and systemic inflammation. We discuss the impact of obesity on systemic therapy resistance and review current evidence supporting pharmacological, surgical, and lifestyle modifications for addressing obesity in the context of improving breast cancer survivorship. Summary: Obesity is associated with poorer survival in breast cancer. Risk stratification by tumor and host-specific characteristics can help identify adjunctive interventions to improve breast cancer outcomes in patients with obesity. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; review; systemic therapy; outcome assessment; recurrence risk; breast cancer; inflammation; obesity; recurrence; risk factor; cancer mortality; risk assessment; survivorship; hormonal therapy; lifestyle modification; tumor microenvironment; molecularly targeted therapy; bariatric surgery; human; breast cancer recurrence |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 16 |
| Issue: | 2 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2024-06-01 |
| Start Page: | 237 |
| End Page: | 250 |
| Language: | English |
| DOI: | 10.1007/s12609-024-00550-5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Neil Iyengar -- Source: Scopus |
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