The impact of obesity on breast cancer Journal Article
| Authors: | Argolo, D. F.; Hudis, C. A.; Iyengar, N. M. |
| Article Title: | The impact of obesity on breast cancer |
| Abstract: | The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, atherosclerosis, stroke, musculoskeletal disorders, and a diverse range of malignances—such as breast cancer. Obesity is associated with an increased risk of postmenopausal estrogen receptor-positive breast cancer and worse cancer-related outcomes for all breast tumor subtypes. Several mechanisms have been proposed to contribute to the obesity-cancer link, including high levels of circulating and local estrogens, altered amounts of adipokines (leptin and adiponectin), disrupted insulin/IGF signaling, modifications within the microbiome, and local and systemic effects of inflammation. Here we will review recent advances in our understanding of the complex signaling pathways underlying the obesity-cancer link. An improved understanding of these processes is anticipated to propel novel and effective intervention strategies to reduce the global obesity-cancer burden. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | breast cancer; inflammation; obesity; insulin; adipose tissue; metabolic syndrome |
| Journal Title: | Current Oncology Reports |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2018-06-01 |
| Start Page: | 47 |
| Language: | English |
| DOI: | 10.1007/s11912-018-0688-8 |
| PROVIDER: | scopus |
| PUBMED: | 29644507 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 May 2018 -- Source: Scopus |
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