Ku70: A candidate tumor suppressor gene for murine T cell lymphoma Journal Article
| Authors: | Li, G. C.; Ouyang, H.; Li, X.; Nagasawa, H.; Little, J. B.; Chen, D. J.; Ling, C. C.; Fuks, Z.; Cordon-Cardo, C. |
| Article Title: | Ku70: A candidate tumor suppressor gene for murine T cell lymphoma |
| Abstract: | We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70-/- mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4+CD8+ tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression. |
| Keywords: | dna binding protein; genetics; dna-binding proteins; comparative study; radiation dose; t lymphocyte; t-lymphocytes; mouse; phenotype; animal; mouse mutant; animals; mice; mice, knockout; dna repair; nuclear protein; cell line; cell differentiation; pathology; mice, scid; tumor cells, cultured; protein serine threonine kinase; radiation exposure; physiology; cell transformation, neoplastic; nuclear proteins; chromosome aberration; tumor suppressor gene; t cell lymphoma; lymphoma, t-cell; chemistry; cell culture; cell transformation; protein-serine-threonine kinases; fibroblast; fibroblasts; cell line, transformed; sister chromatid exchange; helicase; chromosome aberrations; ku antigen; thymoma; clonogenic assay; colony-forming units assay; thymus neoplasms; dna helicases; genes, tumor suppressor; radiation tolerance; dna dependent protein kinase; gamma radiation; gamma rays; dna-activated protein kinase; antigens, nuclear; cell nucleus antigen; article; hirschsprung disease; xrcc5 protein, human |
| Journal Title: | Molecular Cell |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 1097-2765 |
| Publisher: | Cell Press |
| Date Published: | 1998-07-01 |
| Start Page: | 1 |
| End Page: | 8 |
| Language: | English |
| PUBMED: | 9702186 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S1097-2765(00)80108-2 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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