Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia Journal Article

  


Authors: Leventhal, L.; Mathis, J. P.; Rossi, G. C.; Pasternak, G. W.; Bodnar, R. J.
Article Title: Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia
Abstract: Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.
Keywords: controlled study; exon; exons; nonhuman; binding affinity; mass spectrometry; animals; animal experiment; feeding; food intake; molecular cloning; eating; amino acid sequence; nucleotide sequence; rat; rats; high performance liquid chromatography; rats, sprague-dawley; oligonucleotide; hyperalgesia; opiate receptor; naltrexone; oligonucleotides, antisense; opioid peptides; nociceptin; orphanin fq/nociceptin; narcotic antagonists; receptors, opioid; male; priority journal; article; hyperphagia; orl1/kor-3 clone; orphan drug
Journal Title: European Journal of Pharmacology
Volume: 349
Issue: 1
ISSN: 0014-2999
Publisher: Elsevier B.V.  
Date Published: 1998-05-15
Start Page: R1
End Page: R3
Language: English
DOI: 10.1016/s0014-2999(98)00272-6
PUBMED: 9669488
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032524789&doi=10.1016%2fS0014-2999%2898%2900272-6&partnerID=40&md5=31e703a40c70f8ec4dca7a208d9b8f34
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Grace Rossi
    61 Rossi
  2. Gavril W Pasternak
    414 Pasternak
  3. John P Mathis
    21 Mathis
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